General
Preferred name
DIHYDREXIDINE HYDROCHLORIDE
Synonyms
Dihydrexidine (hydrochloride) ()
DAR-0100 (hydrochloride) ()
P&D ID
PD021890
CAS
158704-02-0
137417-08-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity[1][2][3][4]. Dihydrexidine hydrochloride can stimulate YAP phosphorylation[5].
DESCRIPTION Selective D1-like agonist (Tocriscreen Total)
DESCRIPTION The hydrochloride salt form of Dihydrexidine, which has been found to be an effective full efficacy dopamine D1 agonist and show antiparkinsonism effects in vivo. (BOC Sciences Bioactive Compounds)
DESCRIPTION alpha2 agonist. Also I2 selective ligand (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
5
BOC Sciences Bioactive Compounds
dihydrexidine-hydrochloride-cas-158704-02-0-item-169814
CZ-OPENSCREEN Bioactive Library
MedChem Express Bioactive Compound Library
HY-101299B
Tocris Bioactive Compound Library
0884
Tocriscreen Total
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
303.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
3.07
TPSA
52.49
Fraction CSP3
0.29
Chiral centers
2.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
D1 and D5 Receptors
MOA
Agonist
Target
Dopamine Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Source data