General
Preferred name
Norclozapine
Synonyms
N-DESMETHYLCLOZAPINE ()
Desmethylclozapine ()
Normethylclozapine ()
N-Demethylclozapine ()
N-Desmethylclozapine-d8 ()
P&D ID
PD021872
CAS
6104-71-8
1189888-77-4
Tags
available
drug candidate
Drug indication
Schizophrenia
Schizoaffective disorder
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a ¦Ä-opioid agonist[1][2].
DESCRIPTION 5-HT2C antagonist (Tocriscreen Total)
Compound Sets
8
Axon Medchem Screening Library
2846
Cayman Chemical Bioactives
26153
26027
Drug Repurposing Hub
DrugBank
DB05766
DrugMAP
DMVIRN3
MedChem Express Bioactive Compound Library
HY-G0021
Novartis Chemogenetic Library (NIBR MoA Box)
Tocriscreen Total
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
312.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
3.38
TPSA
39.66
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
7.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
¦Ä-opioid receptor
HTR2C
Clozapine metabolite
Drug Metabolite
mAChR
Opioid Receptor
Virus Protease
MOA
5-HT Receptor antagonist
Dopamine Receptor antagonist
Opioid Receptor agonist
Muscarinic M1 Agonists
5-HT2A Inverse Agonists
Dopamine D3 Partial Agonists
Dopamine D2 Receptor Partial Agonists
acetylcholine receptor agonist
Member status
member
Pathway
Anti-infection
GPCR/G protein
Metabolic Enzyme/Protease
Neuronal Signaling
Source data