General
Preferred name
CHPG
Synonyms
CHPG hydrochloride(170846-74-9 Free base) ()
CHPG Sodium salt ()
CHPG (sodium salt) ()
CHPG hydrochloride ()
CHPG ()
P&D ID
PD021863
CAS
170846-74-9
1303993-73-8
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-¦ÊB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2].
PRICE
33
PRICE
114
DESCRIPTION
Selective 5-HT2C antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
mGlu5 selective agonist
(Tocriscreen Total)
DESCRIPTION
CHPG is a selective metabotropic glutamate 5 (mGlu5) receptor agonist, and it is inactive in CHO cells. CHPG potentiates NMDA-induced depolarizations in rat hippocampal slices, and promotes proliferation of human embryonic cortical NSCs with activation of the MAPKs signaling pathway.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Non-selective mGlu antagonist; disodium salt of (RS)-MCPG (Cat. No. 0336)
(Tocris Bioactive Compound Library)
DESCRIPTION
The sodium salt of CHPG, which is the selective metabotropic glutamate 5 (mGlu5) receptor agonist.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
CHPG sodium salt is a selective agonist of mGluR5 that activates ERK and Akt signaling pathways and is utilized in studies on traumatic brain injury.
(TargetMol Bioactive Compound Library)
DESCRIPTION
CHPG hydrochloride is a selective agonist of mGluR5.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
Guide to Pharmacology
Ki Database
MedChem Express Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
201.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
1.13
TPSA
83.55
Fraction CSP3
0.12
Chiral centers
1.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mGlu5
NF-κB
ERK
mGluR5 agonist
Akt
mGluR
Primary Target
Glutamate (Metabotropic) Group I Receptors
MOA
Agonist
Pathway
Neuroscience
MAPK
GPCR/G protein
MAPK/ERK Pathway
Neuronal Signaling
PI3K/Akt/mTOR
Stem Cell/Wnt
NF-¦ÊB
Source data
