General
Preferred name
(S)-(+)-Niguldipine hydrochloride
Synonyms
P&D ID
PD021845
CAS
113145-69-0
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
alpha1 antagonist, L-type Ca2+ channel blocker
(Tocriscreen Plus)
DESCRIPTION
alpha1 antagonist, L-type Ca2+ channel blocker. Less active enantiomer of Niguldipine hydrochloride (Cat. No. 1123)
(Tocris Bioactive Compound Library)
DESCRIPTION
α1 antagonist, L-type Ca2+ channel blocker
(Tocriscreen Total)
DESCRIPTION
(S)-(+)-Niguldipine hydrochloride, the more active enantiomer of Niguldipine hydrochloride, acts as a potent, selective α1A-adrenoceptor antagonist (Ki = 0.16 nM), and also is a L-type Ca2+ channel blocker.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
BOC Sciences Bioactive Compounds
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
11
Molecular Weight
645.26
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
10
Ring Count
5
Aromatic Ring Count
3
cLogP
6.44
TPSA
111.01
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.12
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
Adrenergic ?1 Receptors
MOA
Antagonist
Source data
