General
Preferred name
cyclopiazonic acid
Synonyms
Cyclopiazonic Acid-13C20 ()
P&D ID
PD021832
CAS
18172-33-3
Tags
available
drug candidate
natural product
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 ¦Ì M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B[1][4][5].
DESCRIPTION
Inhibitor of SERCA ATPase
(Tocris Bioactive Compound Library)
DESCRIPTION
Inhibitor of SERCA ATPase
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
7
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
336.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
2
cLogP
2.83
TPSA
73.4
Fraction CSP3
0.4
Chiral centers
3.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Ca2+-ATPase
MOA
Inhibitor
ATPase inhibitor
Target
ATP2A1
5-HT Receptor
Apoptosis
Calcium Channel
MDM-2/p53
RSV
Pathway
Anti-infection
GPCR/G protein
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
