General
Preferred name
Rimcazole dihydrochloride
Synonyms
BW 234U (dihydrochloride) ()
Rimcazole (dihydrochloride) ()
BW 234U DIHYDROCHLORIDE ()
RIMCAZOLE HYDROCHLORIDE ()
P&D ID
PD021828
CAS
75859-03-9
108050-82-4
Tags
drug candidate
natural product
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GABA uptake inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION σ2 antagonist. Also DAT inhibitor (Tocriscreen Total)
DESCRIPTION Rimcazole dihydrochloride is a small molecule antagonist of the σ-1 receptor (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively). (BOC Sciences Bioactive Compounds)
Compound Sets
5
ChEMBL Drugs
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
393.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
4.71
TPSA
20.2
Fraction CSP3
0.43
Chiral centers
2.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
?2 Receptors
MOA
Antagonist
Pathway
GPCR/G protein
Neuronal Signaling
Target
Dopamine Receptor
Sigma Receptor
Source data