General
Preferred name
YM-976
Synonyms
YM 976 ()
YM976 ()
P&D ID
PD021792
CAS
191219-80-4
Tags
available
drug candidate
Drug indication
Asthma
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PDE4 inhibitor (Tocriscreen Plus)
DESCRIPTION PDE4 inhibitor (Tocriscreen Total)
DESCRIPTION YM 976 is an orally bioactive PDE4 inhibitor (IC50 = 2.2 nM). YM 976 inhibits PDE4 to maintain cAMP and prolong signal transduction. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
14
BOC Sciences Bioactive Compounds
ym-976-cas-191219-80-4-365540
Cayman Chemical Bioactives
29529
Concise Guide to Pharmacology 2017/18
5292
Concise Guide to Pharmacology 2019/20
5292
Concise Guide to Pharmacology 2021/22
5292
Concise Guide to Pharmacology 2023/24
5292
Drug Repurposing Hub
DrugMAP
DMCDK6S
Guide to Pharmacology
5292
MedChem Express Bioactive Compound Library
HY-108617
ReFrame library
TargetMol Bioactive Compound Library
T7954
Tocriscreen Plus
1821
Tocriscreen Total
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
313.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
3.69
TPSA
47.78
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.74
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
PDE4
PDE4A
Phosphodiesterase (PDE)
MOA
phosphodiesterase inhibitor
Source data