General
Preferred name
UBP 296
Synonyms
P&D ID
PD021776
CAS
745055-86-1
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective, potent kainate antagonist; selective for GluR5-containing receptors
(Tocriscreen Total)
DESCRIPTION
UBP 296 is a selective GLUK5 (GluR5)-subunit containing kainate receptor antagonist (apparent KD = 1.09 μM) that displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. It has no activity at NMDA or group I mGlu receptors. UBP 296 was shown to selectively block kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
BOC Sciences Bioactive Compounds
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
12
Molecular Weight
333.1
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
-0.83
TPSA
144.62
Fraction CSP3
0.2
Chiral centers
1.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Kainate Receptors
MOA
Antagonist
Source data
