General
Preferred name
QUINAZOLINONE
Synonyms
4-HQN ()
Quinazolin-4-ol ()
4-Hydroxyquinazoline ()
4-Quinazolinol ()
4-Quinazolone ()
4-Quinazolinone ()
3,4-dihydroquinazolin-4-one ()
4(3H)-Quinazolinone ()
Quinazolin-4-ol, 4-Quinazolinol ()
P&D ID
PD021738
CAS
491-36-1
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
4(3H) -quinazolinone is a fused nitrogen heterocyclic compound whose derivatives have a wide range of antimicrobial and antitumor activities[1][2].
PRICE
29
DESCRIPTION
PARP inhibitor
(Tocriscreen Total)
DESCRIPTION
4-HQN is a poly(ADP-ribose) polymerase (PARP) inhibitor (IC50 = 9.5 μM). 4-HQN exhibits antianti-ischemic activity and reduces ROS production, subsequent mitochondrial and cell damage in rat heart. It also blocks NF-κB and AP-1 activation.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
4(3H)-Quinazolinone inhibits poly [ADP-ribose] polymerase 1 with IC50 = 9.5 nM. It has anticancerous, antibacterial, antithrombocytic and anti-inflammatory activities.
(Enamine Bioactive Compounds)
DESCRIPTION
4(3H)-Quinazolinone (4-Hydroxyquinazoline) is a chemically synthesized masonry block, a biologically active nitrogen heterocyclic compound. It possesses various biological properties such as antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and pain relieving activities.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
146.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
1.34
TPSA
46.01
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Bacterial
Platelet aggregation
PARP1
EGFR
PARP
MOA
antiplatelet
PARP inhibitor
Pathway
Microbiology/virology
Anti-infection
JAK/STAT Signaling
Protein Tyrosine Kinase/RTK
Source data
