General
Preferred name
CGH 2466 dihydrochloride
Synonyms
P&D ID
PD021721
CAS
1177618-54-0
Tags
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
CGH 2466 dihydrochloride is an adenosine A1, A2B and A3 receptor antagonist (IC50 = 19, 21, and 80 nM, respectively). It also displays an inhibitory effect on p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). CGH 2466 is potentially used for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
A1, A2B and A3 antagonist and inhibitor of p38 MAPK and PDE4
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
2
BOC Sciences Bioactive Compounds
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
6
Molecular Weight
392.94
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
5.6
TPSA
51.8
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Source data
