General
Preferred name
Hyodeoxycholic Acid
Synonyms
NSC 60672 ()
α-Hyodeoxycholic Acid ()
HDCA ()
3α,6α-Dihydroxy-5β-cholan-24-oic acid, HDCA ()
¦Á-Hyodeoxycholic Acid ()
3??,6??-Dihydroxy-5??cholan-24-oic acid, HDCA ()
Hyodeoxycholic acid (HDCA) ()
HYODEOXYCHOLIC_ACID ()
Hyodeoxycholic Acid ()
NSC-60672 ()
.alpha.-hyodeoxycholic acid ()
AHRO-001 ()
Hyodesoxycholic acid ()
Hyodeoxycholic Acid MaxSpec® Standard ()
P&D ID
PD021621
CAS
83-49-8
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
Drug indication
Hypercholesterolemia
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 ¦ÌM in CHO cells.
DESCRIPTION
Hyodeoxycholic acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria. It is a TGR5 (GPCR19) agonist, with an EC50 of 31.6 μM in CHO cells.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
(Enamine Bioactive Compounds)
DESCRIPTION
Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
9
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
Enamine Bioactive Compounds
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
392.29
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
0
cLogP
4.48
TPSA
77.76
Fraction CSP3
0.96
Chiral centers
10.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
FXR
GPCR19
TGR5
G protein-coupled Bile Acid Receptor 1
MOA
atherosclerosis formation inhibitor
Pathway
GPCR/G protein
Metabolism
Metabolic Enzyme/Protease
Solubility
Soluble in DMSO (Slightly), Ethanol (Sparingly), Methanol (Slightly)
Source data
