General
Preferred name
GOLGICIDE A
Synonyms
GCA ()
P&D ID
PD021599
CAS
1139889-93-2
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent, specific and reversible inhibitor of GBF1 ArfGEF (Tocriscreen Plus)
DESCRIPTION Potent DGAT-1 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
0
Compound Sets
9
AdooQ Bioactive Compound Library
A16561
BOC Sciences Bioactive Compounds
golgicide-a-cas-1139889-93-2-item-84-261662
Mcule NIBR MoA Box Subset
MCULE-4438190625
MedChem Express Bioactive Compound Library
HY-100540
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
golgicide-a
TargetMol Bioactive Compound Library
T6516
Tocris Bioactive Compound Library
3584
Tocriscreen Plus
3584
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
284.11
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
2
cLogP
4.19
TPSA
24.92
Fraction CSP3
0.24
Chiral centers
3.0
Largest ring
6.0
QED
0.79
Structural alerts
1
anil_alk_ene(51)
c:1:c:c-2:c(:c:c:1)-[#6]-3-[#6](-[#6]-[#7]-2)-[#6]-[#6]=[#6]-3
PAINS Family B
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
GBF1
Enterovirus
ATPase
Primary Target
Arf GTPases
MOA
Inhibitor
Golgi-Specific Brefeldin A-Resistance Guanine Nucleotide Exchange Factor 1 (GBF1) Inhibitors
Member status
member
Pathway
Anti-infection
Solubility
Soluble in DMSO
Source data