General
Preferred name
ravoxertinib
Synonyms
GDC-0994 ()
GDC0994 ()
Ravoxertinib hydrochloride ()
RG-7842 ()
GDC-0994 (hydrochloride) ()
Ravoxertinib (GDC-0994) ()
GDC-0994 ()
P&D ID
PD021570
CAS
1453848-26-4
2070009-58-2
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Drug Status
investigational
Max Phase
Phase 1
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ravoxertinib (GDC-0994) is an orally available, small molecule selective inhibitor of extracellular signal-regulated kinase 1/2 (ERK1/2) in early clinical development . It is compound 22 in . ERK1 is formally known as mitogen-activated protein kinase 3 (MAPK3) and ERK2 as mitogen-activated protein kinase 1 (MAPK1). GDC-0994 is example 39 claimed in patent WO2013130976 .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Clinical kinase drugs
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LINCS compound set
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
440.12
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
3.16
TPSA
97.86
Fraction CSP3
0.14
Chiral centers
1.0
Largest ring
6.0
QED
0.48
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Targets
MAPK3,MAPK1
Pathway
MAPK
MAPK/ERK Pathway
Stem Cell/Wnt
Target
ERK1
ERK2
MAPK1, MAPK3
ERK
MOA
ERK1 and ERK2 phosphorylation inhibitor
Source data
