General
Preferred name
CPI-169
Synonyms
CPI-169 R-enantiomer ()
HY-15956A ()
AKOS025404937 ()
CS-3174 ()
P&D ID
PD021541
CAS
1450655-76-1
Tags
available
probe
Probe info
Probe type
P&D approved
experimental probe
calculated probe
Probe selectivity
protein-selective
Probe sources
Chemical Probes.org
High-quality chemical probes
Tool Compound Set
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
COMMENT Jul 31 2016 - 4:53pm; CPI-169 is a member of a family of structurally related, pyridone based EZH2 inibitors that also includes compounds such as UNC1999 and GSK-343. With the exception of EZH1, CPI-169 is highly selective and is suitable for both in vitro cell assays and in vivo work. The compound is not orally biovailable; however, in vivo PD modulation and efficacy in a tumor xenograft model was demonstated using subcutaneous administraton via a a twice daily dosing. Aug 19 2016 - 8:52pm; Subcutaneous treatment with CPI-169 (200 mg/kg twice daily) in KARPAS-422 mouse xengraft model showed >60%% tumor growth inhibition after 28 days. Sep 9 2016 - 5:12pm
MOA SAM competitive inhibitor (Chemical Probes.org)
Compound Sets
9
AdooQ Bioactive Compound Library
A15920
Chemical Probes.org
cpi-169
Drug Repurposing Hub
EUbOPEN Chemogenomics Library
EUB0002214
High-quality chemical probes
PD021541
Mcule NIBR MoA Box Subset
MCULE-3660184242
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
cpi-169
Tool Compound Set
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
528.24
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
3.51
TPSA
113.5
Fraction CSP3
0.48
Chiral centers
1.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Histone-lysine N-methyltransferase EZH2
Epigenetic Reader Domain
EZH2
EZH1, EZH2
EZH1/2,Histone Methyltransferase
EZH2, EZH1
Member status
member
MOA
EZH2 gene inhibitor
histone lysine methyltransferase inhibitor
Target subclass
Protein methyltransferase
Protein methyltransferase, Protein methyltransferase
Target class
Epigenetics
Epigenetic, Epigenetic
Orthogonal probe
UNC1999
Recommended Cell Concentration
None
Source data