General
Preferred name
BI-847325
Synonyms
P&D ID
PD021540
CAS
1207293-36-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BI-847325 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. BI-847325 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PRICE 146
DESCRIPTION BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. (TargetMol Bioactive Compound Library)
Compound Sets
7
AdooQ Bioactive Compound Library
A15762
Clinical kinase drugs
EU-OPENSCREEN Bioactive Compound Library
EOS100528
MedChem Express Bioactive Compound Library
HY-18955
ReFrame library
Selleckchem Bioactive Compound Library
bi-847325
TargetMol Bioactive Compound Library
T6785
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
464.22
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
4.17
TPSA
73.47
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Targets
MAP2K1,MAP2K2,AURKA,AURKB,AURKC
Target
Apoptosis
Aurora A (Human)
Aurora B (Xenopus laevis)
Aurora C (Human)
Aurora Kinase
MEK
MEK1
MEK2
Aurora Kinase,MEK
Pathway
Cell Cycle/Checkpoint
Chromatin/Epigenetic
MAPK
Cell Cycle/DNA Damage
Epigenetics
MAPK/ERK Pathway
Source data