General
Preferred name
S107
Synonyms
S-107 ()
S107 hydrochloride ()
P&D ID
PD021453
CAS
1357476-46-0
927871-76-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca2+ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold[1][2].
PRICE 50
DESCRIPTION S107 is a RyR-selective 1, 4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels. (TargetMol Bioactive Compound Library)
Compound Sets
8
AdooQ Bioactive Compound Library
A12716
Cayman Chemical Bioactives
13253
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
EOS100130
MedChem Express Bioactive Compound Library
HY-15292
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
s107
s107-hydrochloride
TargetMol Bioactive Compound Library
T3438
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
209.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
2.23
TPSA
12.47
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
7.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
Ryanodine receptor modulator
RyR1/FKBP12 Complex Stabilzer
Drugs Acting on Ryanodine Receptor (RyR) Channels
Target
Calcium Channel
Calcium Channel,FKBP
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data