General
Preferred name
CAY10599
Synonyms
P&D ID
PD021445
CAS
1143573-33-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Peroxisome proliferator-activated receptor gamma (PPARγ), also known as the glitazone receptor, or NR1C3, is a type II nuclear receptor that in humans is encoded by the PPARG gene. CAY10599 is a PPARγ agonist that is 4-fold more potent than rosiglitazone at PPARγ with an EC50 of 0.05 μM. It shows high selectivity for the PPARγ receptor over PPARβ (EC50 > 10 μM) or PPARα (EC50 = 3.99 μM). (BOC Sciences Bioactive Compounds)
Compound Sets
2
BOC Sciences Bioactive Compounds
cay10599-cas-1143573-33-4-item-311186
Cayman Chemical Bioactives
13282
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
591.3
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
13
Ring Count
5
Aromatic Ring Count
4
cLogP
8.0
TPSA
76.07
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Solubility
Soluble to 25 mg/ml in ethanol, to 25 mg/ml in DMSO, to 25 mg/ml in DMF.
Source data