General
Preferred name
ARP 100
Synonyms
MMP-2 Inhibitor III ()
ARP100 ()
ARP-100 ()
MMP-2 Inhibitor III, Compound 10a ()
P&D ID
PD021431
CAS
704888-90-4
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1£§ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 ¦ÌM), MMP-3 (4.5 ¦ÌM), MMP-7 (>50 ¦ÌM), and MMP-9 (0.2 ¦ÌM)[1][2].
PRICE 79
DESCRIPTION ARP-100 (MMP-2 Inhibitor III) is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion Matrigel model. ARP-100 has low inhibitory activity against MMP-1 (>50 ??M), MMP-3 (4.5 ??M), MMP-7 (>50 ??M) and MMP-9 (0.2 ??M)[1][2].
DESCRIPTION ARP 100 has been found to be a selective inhibitor of MMP-2 and could show anti-invasive properties in HT1080 fibrosarcoma cells at some extent. (BOC Sciences Bioactive Compounds)
DESCRIPTION ARP-100 (MMP-2 Inhibitor III) is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion Matrigel model. ARP-100 has low inhibitory activity against MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM) and MMP-9 (0.2 μM)[1][2]. (TargetMol Bioactive Compound Library)
DESCRIPTION Inhibitor of MMP-2 (Tocris Bioactive Compound Library)
Compound Sets
12
BOC Sciences Bioactive Compounds
arp-100-cas-704888-90-4-item-129473
Cayman Chemical Bioactives
13321
Concise Guide to Pharmacology 2017/18
5140
Concise Guide to Pharmacology 2019/20
5140
Concise Guide to Pharmacology 2021/22
5140
Concise Guide to Pharmacology 2023/24
5140
DrugMAP
DM6KQXF
Guide to Pharmacology
5140
MedChem Express Bioactive Compound Library
HY-103444
Selleckchem Bioactive Compound Library
arp-100
TargetMol Bioactive Compound Library
T14322
Tocris Bioactive Compound Library
2621
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
364.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
2.19
TPSA
95.94
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
MMP
MMP-1
MMP-2
MMP-3
MMP-7
MMP-9
Primary Target
Matrix Metalloproteases
MOA
Inhibitor
Pathway
Metabolic Enzyme/Protease
Proteases/Proteasome
Source data