General
Preferred name
TPEN
Synonyms
TPEDA ()
T1210 ()
P&D ID
PD021426
CAS
16858-02-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn2+, but a lower affinity for Mg2+ and Ca2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis[1][2][3].
DESCRIPTION TPEN is a heavy metal chelator that acts as an intracellular chelator of proteomic Zn2+. TPEN decreases intracellular zinc levels, and induces apoptosis in HeLa and cultured human retinal pigment epithelium (RPE) cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
7
AdooQ Bioactive Compound Library
A11980
BOC Sciences Bioactive Compounds
tpen-cas-16858-02-9-51698
Cayman Chemical Bioactives
13340
MedChem Express Bioactive Compound Library
HY-100202
ReFrame library
Selleckchem Bioactive Compound Library
tpen
TargetMol Bioactive Compound Library
T3952
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
424.24
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
11
Ring Count
4
Aromatic Ring Count
4
cLogP
3.97
TPSA
58.04
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.36
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Autophagy
Immunology/Inflammation
Metabolism
NF-κB
Metabolic Enzyme/Protease
NF-¦ÊB
Target
Apoptosis related,NOS
Reactive Oxygen Species (ROS)
Reactive Oxygen Species
Source data