General
Preferred name
N-Oleoyl-L-Serine
Synonyms
N-Oleoylserine ()
P&D ID
PD021255
CAS
107743-37-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION N-Oleoyl-L-Serine (N-Oleoylserine) is an endogenous long-chain fatty acid amide that is a lipid modulator of bone remodeling and stimulates osteoclast apoptosis which can be used to study osteoporosis. N-Oleoyl-L-Serine showed high activity in an osteoblast proliferation assay.N-Oleoyl-L-Serine promotes osteoclast apoptosis by inhibiting Erk1/2 phosphorylation and expression of nuclear κB ligand (RANKL) receptor activator in bone marrow stromal cells and osteoblasts, which attenuates osteoclast populations. (TargetMol Bioactive Compound Library)
Compound Sets
2
Cayman Chemical Bioactives
13058
TargetMol Bioactive Compound Library
T36065
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
369.29
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
18
Ring Count
0
Aromatic Ring Count
0
cLogP
4.59
TPSA
86.63
Fraction CSP3
0.81
Chiral centers
1.0
Largest ring
0.0
QED
0.24
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Apoptosis
Source data