General
Preferred name
exo-IWR 1
Synonyms
exo-IWR-1 ()
IWR-1-exo ()
P&D ID
PD021195
CAS
1127442-87-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Negative control for endo-IWR 1 (Cat. No. 3532) (Tocriscreen Plus)
DESCRIPTION Arp2/3 inhibitor; inhibits actin polymerization (Tocris Bioactive Compound Library)
DESCRIPTION exo-IWR 1, the enantiomer of IWR-1 and the diastereomer of IWR-1-endo, is a potent SAR anticancer Wnt response inhibitor, which is a kind of small secreted proteins and are active in tissue homeostasis, tumorigenesis and embryonic development. It shows decreased activity against the Wnt/β-catenin pathway. It may be an ideal control for tests involving the active form, IWR-1-endo. It may be used in the treatment of some diseases and conditions such as degenerative diseases, cancers, osteopetrosis and type II diabetes. (BOC Sciences Bioactive Compounds)
Compound Sets
8
BOC Sciences Bioactive Compounds
exo-iwr-1-cas-1127442-87-8-item-272159
Cayman Chemical Bioactives
13598
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
HY-108437
TargetMol Bioactive Compound Library
T22775
Tocris Bioactive Compound Library
3947
Tocriscreen Plus
3947
ZINC Tool Compounds
ZINC000000915717
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
409.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
6
Aromatic Ring Count
3
cLogP
3.8
TPSA
79.37
Fraction CSP3
0.2
Chiral centers
4.0
Largest ring
6.0
QED
0.53
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Pathway
Cytoskeletal Signaling
Stem Cells
Stem Cell/Wnt
Target
Wnt
TNKS
Primary Target
?-catenin
MOA
WNT signaling inhibitor negative control
Source data