General
Preferred name
MUSCIMOL
Synonyms
MUSCIMOL HYDROBROMIDE ()
Agarin hydrobromide ()
Agarin HBr ()
Muscimol HBr ()
[3H]muscimol ()
NSC-333569 ()
Pantherine ()
Agarin ()
Muscimol hydrochloride ()
Muscimol (CRM) ()
P&D ID
PD021173
CAS
2763-96-4
2489-10-3
18174-72-6
3579-03-1
Tags
available
drug candidate
Drug indication
Discovery agent
Epilepsy
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 235
DESCRIPTION Potent GABAA agonist (Tocriscreen Total)
DESCRIPTION Highly potent and subtype-selective kainate agonist (Tocris Bioactive Compound Library)
DESCRIPTION GABA-A receptor agonist, water soluble (LOPAC library)
DESCRIPTION Muscimol HBr (Agarin HBr) is an agonist of GABAA receptor. (TargetMol Bioactive Compound Library)
DESCRIPTION Muscimol is a full GABAA agonist and partial GABAC agonist. It binds GABAA, Ki = 1.8. (Enamine Bioactive Compounds)
Compound Sets
24
AdooQ Bioactive Compound Library
A13459
Cayman Chemical Bioactives
13667
38030
ChEMBL Drugs
CHEMBL273481
Concise Guide to Pharmacology 2017/18
4090
4259
Concise Guide to Pharmacology 2019/20
4090
4259
Concise Guide to Pharmacology 2021/22
4090
4259
Concise Guide to Pharmacology 2023/24
4090
4259
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB12458
DrugMAP
DMNTF2O
DrugMatrix
Enamine Bioactive Compounds
EBC-251216
EU-OPENSCREEN Bioactive Compound Library
EOS102325
Guide to Pharmacology
4090
4259
Ki Database
Muscimol
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL273481
Mcule NIBR MoA Box Subset
MCULE-5314463544
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T20657
Tocris Bioactive Compound Library
0289
Tocriscreen Total
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
114.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.16
TPSA
72.28
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
5.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
GABA-A, GABA-C
Target
GABAA
GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRR1, GABRR2, GABRR3
Primary Target
GABAA Receptors
MOA
Agonist
GABA A receptor agonist
benzodiazepine receptor agonist
Member status
member
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Source data