General
Preferred name
Leukotriene C4
Synonyms
LTC4 ()
LTC4 ()
Leukotriene C4-d5 ()
P&D ID
PD021020
CAS
10-34-4
72025-60-6
1441421-73-3
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Drug Status
experimental
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Leukotriene C4 is a cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 acts as an agonist of smooth muscle contraction. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugMAP
Guide to Pharmacology
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
625.3
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
7
Rotatable Bonds
25
Ring Count
0
Aromatic Ring Count
0
cLogP
2.78
TPSA
216.35
Fraction CSP3
0.57
Chiral centers
4.0
Largest ring
0.0
QED
0.04
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
