General
Preferred name
Sphingosine-1-phosphate (d18:1)
Synonyms
Sphingosine-1-phosphate ()
S1P ()
sphingosine 1-phosphate ()
[32P]S1P ()
Sphingosine-1-phosphate-d7 (d18:1) ()
P&D ID
PD020885
CAS
26993-30-6
2260670-15-1
Tags
available
drug candidate
Drug indication
Acne vulgaris
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sphingosine 1-phosphate (S1P) is a zwitterionic lyso-phospholipid product of the sphingosine biosynthetic pathway. It is a result of the phosphorylation of sphingosine by two well characterised kinases, SPHK1 and SPHK2 (sphingosine kinase 1 and 2). SPHK1 is predominately extracellular and SPHK1 intracellular. Sphingosine itself is produced by the N-deacylation of ceramide by the enzyme ceramidase.
(GtoPdb)
PRICE
494
DESCRIPTION
This is a radio-labelled analogue of the bioactive lipid pphingosine 1-phosphate (S1P).
(GtoPdb)
DESCRIPTION
Sphingosine-1-phosphate is an endogenous second messenger that inhibits cell proliferation and motility, and Ca2+ mobilization to prevent tumor cell metastasis. Sphingosine-1-phosphate acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, and GPR12. As an intracellular second messenger, it mobilizes Ca2+ and acts as an extracellular ligand for G-protein coupled receptors. This important lipid mediator is generated from sphingosine or other membrane phospholipids.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
EUbOPEN Chemogenomics Library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
379.25
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
17
Ring Count
0
Aromatic Ring Count
0
cLogP
4.04
TPSA
113.01
Fraction CSP3
0.89
Chiral centers
2.0
Largest ring
0.0
QED
0.17
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Metabolism
Metabolic Enzyme/Protease
Member status
virtual
MOA
S1PR2 agonist
S1PR3 agonist
S1PR4 agonist
S1PR5 agonist
Target
Endogenous Metabolite
LPL Receptor
S1P1
Solubility
Soluble in 0.3M NaOH (~4 mg/ml). Insoluble in water.
Recommended Cell Concentration
None
Source data
