General
Preferred name
LATREPIRDINE
Synonyms
Dimebon dihydrochloride ()
Dimebon ()
Dimebolin ()
Latrepirdine (dihydrochloride) ()
2016-06-07: PF-1913539 ()
LATREPIRDINE DIHYDROCHLORIDE ()
Dimebolin dihydrochloride ()
Latrepirdine 2HCl ()
Dimebolin hydrochloride ()
Pf-01913539 ()
Dimebolin (hydrochloride) ()
P&D ID
PD020766
CAS
12687-54-6
1186653-04-2
97657-92-6
3613-73-8
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Neuroprotectant; protects against beta-amyloid neurotoxicity
(Tocriscreen Plus)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
EUbOPEN Chemogenomics Library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
Tocriscreen Plus
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
319.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
3.88
TPSA
21.06
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Target
Amyloid-¦Â
Amyloid-??Histamine Receptor
HRH1, HTR6
Neuroprotectant
5-HT Receptor
Adrenergic Receptor
Amyloid-β
Histamine Receptor
5-HT Receptor,GluR,Histamine Receptor
Member status
member
MOA
NMDA Antagonists
5-HT6 Antagonists
glutamate receptor antagonist
Pathway
Autophagy
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Source data
