General
Preferred name
LATREPIRDINE
Synonyms
Dimebon dihydrochloride ()
Latrepirdine 2HCl ()
Dimebolin dihydrochloride ()
Dimebon ()
Dimebolin ()
2016-06-07: PF-1913539 ()
Latrepirdine (dihydrochloride) ()
LATREPIRDINE DIHYDROCHLORIDE ()
5-(2-{2,8-dimethyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indol-5-yl}ethyl)-2-methylpyridine ()
Dimebolin (hydrochloride) ()
Dimebolin hydrochloride ()
LATREPIRDINA ()
PF-01913539 ()
P&D ID
PD020766
CAS
12687-54-6
1186653-04-2
97657-92-6
3613-73-8
Tags
available
drug candidate
Drug indication
Discovery agent
Alzheimer disease
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, ¦Á-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-¦Â (A¦Â) secretion.
PRICE 780
PRICE 88
DESCRIPTION Dimebolin (Latrepirdine) is a 5-HT6 antagonist.
DESCRIPTION Neuroprotectant; protects against beta-amyloid neurotoxicity (Tocriscreen Plus)
DESCRIPTION Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug. (TargetMol Bioactive Compound Library)
DESCRIPTION Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells (TargetMol Bioactive Compound Library)
Compound Sets
16
AdooQ Bioactive Compound Library
A10312
Axon Medchem Screening Library
1445
Cayman Chemical Bioactives
10011349
9000556
ChEMBL Drugs
CHEMBL2105703
CHEMBL589390
Drug Repurposing Hub
DrugBank
DB11725
DrugMAP
DMV8ZQG
EUbOPEN Chemogenomics Library
EUB0000480
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL589390
MedChem Express Bioactive Compound Library
HY-14537
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
Dimebon
TargetMol Bioactive Compound Library
T6562
H025-0000
Tocriscreen Plus
3201
ZINC Tool Compounds
ZINC000008144259
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
319.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
3.88
TPSA
21.06
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Target
Amyloid-¦Â
Amyloid-??Histamine Receptor
HRH1, HTR6
Neuroprotectant
5-HT Receptor
Adrenergic Receptor
Amyloid-β
Histamine Receptor
5-HT Receptor,GluR,Histamine Receptor
GluR
Pathway
Autophagy
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Member status
member
MOA
NMDA Antagonists
5-HT6 Antagonists
glutamate receptor antagonist
Recommended Cell Concentration
100 nM
Source data