General
Preferred name
N-Omega-Propyl-L-Arginine
Synonyms
Nomega-Propyl-L-arginine hydrochloride ()
Nω-Propyl-L-arginine ()
Nω-Propyl-L-arginine (hydrochloride) ()
N-omega-Propyl-L-arginine (hydrochloride) ()
Nω-Propyl-L-arginine hydrochloride ()
Nωpropyl-L-arginine ()
N.omega.-propyl-L-Arginine ()
P&D ID
PD020667
CAS
2321366-46-3
137361-05-8
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Nωpropyl-L-arginine is a selective inhibitor of neural nitric oxide synthase (nNOS). It is a synthetic Nω-substituted-L-arginine analogue.
(GtoPdb)
DESCRIPTION
Nω-Propyl-L-arginine hydrochloride is a neuronal selective nitric oxide synthase inhibitor and a potent and selective inhibitor of NOS1 (nNOS) (Ki = 57 nM) with 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Selective inhibitor of p38 MAPK
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
216.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
5
Rotatable Bonds
7
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.3
TPSA
111.23
Fraction CSP3
0.78
Chiral centers
1.0
Largest ring
0.0
QED
0.23
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
nNOS
MOA
Inhibitor
Pathway
Immunology/Inflammation
Target
NO Synthase
Source data
