General
Preferred name
SAPROPTERIN DIHYDROCHLORIDE
Synonyms
6R-BH4 dihydrochloride ()
6R-Tetrahydro-L-biopterin dihydrochloride ()
Sapropterin Hydrochloride ()
Sapropterin (dihydrochloride) ()
(6R)-BH4 (dihydrochloride) ()
(6R)-Tetrahydro-L-biopterin (dihydrochloride) ()
Tetrahydrobiopterin Dihydrochloride, R-THBP Dihydrochloride ()
Biopten ()
T1401 ()
SUN-0588 ()
Kuvan ()
SUN-0588 (Shiratori) ()
T1401 (BIOMARIN) ()
Dapropterin hydrochloride ()
T-1401 ()
Phenoptin ()
(6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride) ()
P&D ID
PD020659
CAS
69056-38-8
Tags
natural product
drug
available
Drug indication
Hyperphenylalaninemia
Drug Status
approved
Max Phase
Phase 4
First approval
2007
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
313.07
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
6
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
-0.86
TPSA
136.29
Fraction CSP3
0.56
Chiral centers
3.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Target
phenylalanine hydroxylas
hydroxylase
Source data
