General
Preferred name
S-NITROSOGLUTATHIONE
Synonyms
SNOG ()
Glutathione thionitrite ()
GSNO ()
Nitrosoglutathione ()
RVC-588 ()
S-Nitroso-L-glutathione ()
GSNO , RVC-588 , S-Nitroso-L-glutathione , Nitrosoglutathione ()
S-Nitrosoglutatione ()
P&D ID
PD020647
CAS
57564-91-7
Tags
available
drug candidate
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
S-Nitrosoglutatione is an endogenous S-nitrosothiol that plays a critical role in nitric oxide signaling and is a source of bioavailable NO. It is an agonist of angiotensin type I receptor.
(Enamine Bioactive Compounds)
DESCRIPTION
SNOG is an amino acid nitric oxide donor that acts as a smooth muscle relaxant and platelet aggregation inhibitor. It also inhibits NF-κB activation, endothelial cell proliferation and cathepsin B (cysteine proteases).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
10
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugBank
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
336.07
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
5
Rotatable Bonds
11
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.72
TPSA
188.25
Fraction CSP3
0.6
Chiral centers
2.0
Largest ring
0.0
QED
0.22
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Angiotensin Receptor
NO
PTPN1
Endogenous Metabolite
MOA
nitric oxide stimulant
Pathway
Endocrinology/Hormones
Immunology/Inflammation
GPCR/G protein
Metabolic Enzyme/Protease
Source data
