General
Preferred name
NADA
Synonyms
N-Arachidonyldopamine ()
N-Arachidonoyl Dopamine ()
N-Arachidonoyl Dopamine-d8 ()
ARACHIDONOYL DOPAMINE ()
P&D ID
PD020617
CAS
199875-69-9
1159908-42-5
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION N-Arachidonyldopamine is a potent and selective endogenous CB1 receptor agonist with a Ki of 250 nM[1]. N-Arachidonyldopamine is also a potent and selective TRPV1 agonist an with EC50 of ~ 50 nM[2].
PRICE 135
DESCRIPTION N-Arachidonoyl dopamine (NADA) is an endocannabinoid isolated from bovine brain. It acts as an agonist of CB1 and inhibitor of vanilloid TRPV1 receptors. NADA promotes calcium mobilization via Gq-dependent processes and some CB1 receptor trafficking. (BOC Sciences Bioactive Compounds)
DESCRIPTION N-Arachidonyldopamine (NADA) is a selective and potent endogenous CB1 receptor agonist (Ki: 250 nM).N-Arachidonyldopamine is also a potent and selective TRPV1 agonist with an EC50 value of ~50 nM. (TargetMol Bioactive Compound Library)
Compound Sets
6
BOC Sciences Bioactive Compounds
nada-cas-199875-69-9-item-70945
Cayman Chemical Bioactives
10007431
90057
DrugMAP
DM3ORGM
Guide to Pharmacology
4261
MedChem Express Bioactive Compound Library
HY-110018
TargetMol Bioactive Compound Library
T62530
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
439.31
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
17
Ring Count
1
Aromatic Ring Count
1
cLogP
6.9
TPSA
69.56
Fraction CSP3
0.46
Chiral centers
0.0
Largest ring
6.0
QED
0.14
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CB1
Cannabinoid Receptor
TRP Channel
Pathway
GPCR/G protein
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data