General
Preferred name
MICROCYSTIN-LR
Synonyms
P&D ID
PD020595
CAS
101043-37-2
Tags
covalent binder
natural product
drug candidate
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Microcystin-LR is a cyclic peptide that is produced by blue-green algae. It is the agent responsible for the effects of human and animal poisoning from ingestion of water contaminated by algal blooms. Mechanistically it is reported as an inhibitor of the protein phosphatases PP1 and PP2A .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
8
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CovBinderInPDB
DrugMAP
Guide to Pharmacology
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
994.55
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
11
Rotatable Bonds
15
Ring Count
2
Aromatic Ring Count
1
cLogP
0.83
TPSA
340.64
Fraction CSP3
0.55
Chiral centers
10.0
Largest ring
25.0
QED
0.04
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
