General
Preferred name
PD020524
Synonyms
2-Fluoropalmitic acid ()
2-fluoro Palmitic Acid ()
P&D ID
PD020524
CAS
16518-94-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 2-Fluoropalmitic acid, an acyl-CoA synthetase inhibitor, acts as a candidate anti-glioma agent. 2-Fluoropalmitic acid suppresses the viability and stem-like phenotype of glioma stem cells (GSCs). 2-Fluoropalmitic acid also inhibits proliferation and invasion of glioma cell lines[1].
PRICE 626
DESCRIPTION 2-Fluoropalmitic acid (2-Fluorohexadecanoic acid), a fatty acid containing fluorine atoms, serves as a potential therapeutic agent for glioblastoma (GBM) by inhibiting the viability, proliferation, and stem-like phenotype of glioma stem cells (GSCs), suppressing the expression of phosphorylated erk, CD133, and SOX-2, and leading to decreased MMP-2 activity and increased methylation of the MGMT promoter.
DESCRIPTION 2-Fluoropalmitic acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase. The length of the carbon chain of the fatty acid species defines the substrate specificity for the different acyl-CoA synthetases (ACS). (BOC Sciences Bioactive Compounds)
Compound Sets
3
BOC Sciences Bioactive Compounds
2-fluoropalmitic-acid-cas-16518-94-8-item-70959
Cayman Chemical Bioactives
90380
MedChem Express Bioactive Compound Library
HY-117651
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
274.23
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
14
Ring Count
0
Aromatic Ring Count
0
cLogP
5.5
TPSA
37.3
Fraction CSP3
0.94
Chiral centers
1.0
Largest ring
0.0
QED
0.42
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Acyltransferase
Pathway
Metabolic Enzyme/Protease
Source data