General
Preferred name
tafluprost acid
Synonyms
AFP-172 ()
Tafluprost (free acid) ()
Tafluprost (free acid)-d4 ()
Tafluprost free acid ()
P&D ID
PD020494
CAS
209860-88-8
Tags
drug candidate
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
This is the active metabolite of .
(GtoPdb)
DESCRIPTION
Tafluprost acid (AFP-172), an active metabolic form of Tafluprost, is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. Tafluprost acid can be used in the research of glaucoma[1][2][3].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
410.19
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
11
Ring Count
2
Aromatic Ring Count
1
cLogP
3.82
TPSA
86.99
Fraction CSP3
0.5
Chiral centers
4.0
Largest ring
6.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Drug Metabolite
Prostaglandin Receptor
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Source data
