General
Preferred name
Docosahexaenoyl Ethanolamide
Synonyms
Synaptamide ()
Dehydroepiandrosteron(DHEA) ()
P&D ID
PD020297
CAS
162758-94-3
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Docosahexaenoyl ethanolamide (DHEA) is the ethanolamine amide of DHA that has been detected in both brain and retina. DHEA binds to the rat brain CB1 receptor with a Ki of 324 nM, which is approximately 10-fold higher than the Ki for AEA. It also inhibits shaker-related voltage-gated potassium channels in brain slightly better than AEA, with an IC50 of 1.5 µM.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
3
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Guide to Pharmacology
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
371.28
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
16
Ring Count
0
Aromatic Ring Count
0
cLogP
5.57
TPSA
49.33
Fraction CSP3
0.46
Chiral centers
0.0
Largest ring
0.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Stem Cell/Wnt
Protein Tyrosine Kinase/RTK
Target
PKA
Solubility
Soluble in Ethanol (5 mg/ml)
Source data
