General
Preferred name
CAY10499
Synonyms
MAGL-IN-5 ()
P&D ID
PD020253
CAS
359714-55-9
Tags
available
probe
Probe info
Probe type
calculated probe
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
4
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
CAY10499 (MAGL-IN-5) is a non-selective lipase inhibitor with IC50 values of 144 nM and 14 nM for monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), respectively. Additionally, CAY10499 exhibits anti-inflammatory and antiviral activities[1][2][3][4].
PRICE
77
DESCRIPTION
CAY10499 is a carbamate-based, non-selective lipase inhibitor, with well documented inhibitory activity at monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) , and other lipases .
(GtoPdb)
DESCRIPTION
Monoglyceride lipase (MGL) plays an important role in the metabolism of the lipid transmitter 2-arachidonoylglycerol (2-AG). CAY10499 is a potent and selective monoglyceride lipase (MGL) inhibitor exhibiting an IC50 of 90 nM for the recombinant enzyme. It is also a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 mM, respectively).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
MAGL-IN-5 is a non-selective lipase inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
6
Organisms
0
Compound Sets
6
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Probe Miner (suitable probes)
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
355.12
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
2.89
TPSA
95.59
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
FAAH
Influenza Virus
MAGL
SARS-CoV
Lipase
Pathway
Metabolism
Anti-infection
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
