General
Preferred name
CAY10554
Synonyms
BML259 ()
CAY10554, cmpd 6 ()
BML-259 ()
P&D ID
PD020218
CAS
267654-00-2
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].
PRICE 44
DESCRIPTION Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. They are key regulators of cell cycle progression and are therefore promising therapeutic targets for cancer and neurodegenerative diseases. CAY10554 is a potent inhibitor of Cdk5 and Cdk2, with IC50 values of 64 and 98 nM, respectively. (BOC Sciences Bioactive Compounds)
DESCRIPTION BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases. (TargetMol Bioactive Compound Library)
Compound Sets
6
BOC Sciences Bioactive Compounds
bml-259-cas-267654-00-2-item-163098
Cayman Chemical Bioactives
10010301
CDK inhibitor database (CDKiDB)
EUbOPEN Chemogenomics Library
EUB0001622
MedChem Express Bioactive Compound Library
HY-108348
TargetMol Bioactive Compound Library
T36964
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
260.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
3.45
TPSA
41.99
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.91
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
CDK2
CDK5
CDK
Pathway
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
Solubility
Soluble to 30mg/ml in DMSO, to 30mg/ml in dimethyl formamide, to 0.25mg/ml in ethanol.
Recommended Cell Concentration
None
Source data