General
Preferred name
LAVENDUSTIN C
Synonyms
5-(2,5-DIHYDROXYBENZYLAMINO)-2-HYDROXYBENZOIC ACID ()
HDBA ()
NSC 666251 ()
P&D ID
PD020212
CAS
125697-93-0
128575-34-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 ¦ÌM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 ¦ÌM) and pp60c-src(+) kinase (IC50=0.5 ¦ÌM) [1][2].
PRICE 96
DESCRIPTION lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase. (TargetMol Bioactive Compound Library)
Compound Sets
4
Cayman Chemical Bioactives
10010329
DrugMatrix
MedChem Express Bioactive Compound Library
HY-W013857
TargetMol Bioactive Compound Library
T4185
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
275.08
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
5
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.11
TPSA
110.02
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
CaMK
EGFR
SRC
tyrosine kinase
MOA
tyrosinase inhibitor
Pathway
Angiogenesis
JAK/STAT Signaling
Neuroscience
Proteases/Proteasome
Tyrosine Kinase/Adaptors
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Source data