General
Preferred name
BIBB 515
Synonyms
BIBB-515 ()
P&D ID
PD020185
CAS
156635-05-1
Tags
drug candidate
available
Drug indication
Arteriosclerosis
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 2,3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. BIBB 515 is a selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. It is concluded that the lipid-lowering effect of BIBB 515 is mainly the result of an inhibition of LDL production rather than due to an increase in LDL catabolism. OSC inhibitors may offer a novel approach for lipid-lowering therapy. (BOC Sciences Bioactive Compounds)
Compound Sets
6
BOC Sciences Bioactive Compounds
bibb-515-cas-156635-05-1-item-162029
Cayman Chemical Bioactives
10010517
DrugMAP
DM6QT9P
MedChem Express Bioactive Compound Library
HY-116175
ReFrame library
ZINC Tool Compounds
ZINC000000598970
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
380.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
4.44
TPSA
41.9
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Solubility
Soluble in ethanol (~0.15 mg/ml), DMSO (5 mM), and DMF (~0.15 mg/ml).
Source data