General
Preferred name
TCS PrP Inhibitor 13
Synonyms
5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One ()
CAY10550 ()
P&D ID
PD020159
CAS
34320-83-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1].
PRICE 49
DESCRIPTION TCS PrP Inhibitor 13 is an antiprion agent that inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). It was also shown to cause the inhibition of PrP expression and a decrease of proliferation and survival in schwannoma cell lines. (BOC Sciences Bioactive Compounds)
DESCRIPTION TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
4
BOC Sciences Bioactive Compounds
tcs-prp-inhibitor-13-cas-34320-83-7-item-410107
Cayman Chemical Bioactives
10010740
MedChem Express Bioactive Compound Library
HY-107662
TargetMol Bioactive Compound Library
T23450
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
281.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
2.74
TPSA
75.81
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Major prion protein
Pathway
Apoptosis
Source data