General
Preferred name
URB937
Synonyms
P&D ID
PD020097
CAS
1357160-72-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION URB937 is an orally active and peripherally restricted FAAH inhibitor (IC50=26.8 nM) and increases anandamide levels. URB937 fails to affect FAAH activity in the brain (not penetrate the blood-brain barrier)[1].
PRICE 55
DESCRIPTION URB937 is a peripherally restricted inhibitor of fatty-acid amide hydrolase (FAAH) . (GtoPdb)
DESCRIPTION URB937 is a potent, peripheral fatty acid amide hydrolase (FAAH) inhibitor with IC50 value of 26.8 nM. It was shown to reduce prostaglandin E2-induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats. (BOC Sciences Bioactive Compounds)
DESCRIPTION URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM). (TargetMol Bioactive Compound Library)
Compound Sets
7
Axon Medchem Screening Library
3359
BOC Sciences Bioactive Compounds
urb937-cas-1357160-72-5-8861
Cayman Chemical Bioactives
10674
Guide to Pharmacology
11817
MedChem Express Bioactive Compound Library
HY-116477
Selleckchem Bioactive Compound Library
urb937
TargetMol Bioactive Compound Library
T8646
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
354.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.58
TPSA
101.65
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
FAAH
FAAH inhibitor
Pathway
Metabolic Enzyme/Protease
Neuronal Signaling
Metabolism
Neuroscience
Source data