General
Preferred name
Ercalcitriol
Synonyms
1alpha, 25-Dihydroxy VD2-D6 ()
1¦Á,25-Dihydroxy Vitamin D2 ()
1??,25-Dihydroxy Vitamin D2 ()
1α,25-Dihydroxy Vitamin D2 ()
1,25-dihydroxy Vitamin D2 ()
1,25-dihydroxyvitamin d2 ()
1.alpha.,25-dihydroxyvitamin d2 ()
1,25-dihydroxyergocalciferol ()
1,25-dihydroxycalciferol ()
RO-17-6218 ()
P&D ID
PD020083
CAS
60133-18-8
Tags
available
drug candidate
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
532
DESCRIPTION
Ercalcitriol (1??,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2 that strengthens immunity by regulating cathelicidin antimicrobial peptide (CAMP) and defensin ??-4 (DEFB4) genes in normal and transformed cells, combating pathogenic infections.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
Other bioactive compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
428.33
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
0
cLogP
5.73
TPSA
60.69
Fraction CSP3
0.71
Chiral centers
7.0
Largest ring
6.0
QED
0.49
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
VD/VDR
VDR
Drug Metabolite
Endogenous Metabolite
Pathway
Vitamin D Related
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
MOA
vitamin D receptor agonist
Source data
