General
Preferred name
Beauvericin
Synonyms
P&D ID
PD020079
CAS
26048-05-5
Tags
available
nuisance
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages[1][2][3][4][5][6][7][8][9].
Cell lines
2
Organisms
0
Compound Sets
4
Cayman Chemical Bioactives
11426
MedChem Express Bioactive Compound Library
HY-N6739
Nuisance compounds in cellular assays
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
783.41
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
0
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
3
cLogP
4.91
TPSA
139.83
Fraction CSP3
0.47
Chiral centers
6.0
Largest ring
18.0
QED
0.22
Structural alerts
1
Nonspecific/NOS
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Cellular injury category
Miscellaneous
Target
Akt
Apoptosis
Bacterial
Fungal
Interleukin Related
PI3K
TNF Receptor
Pathway
Anti-infection
Immunology/Inflammation
PI3K/Akt/mTOR
Source data