General
Preferred name
Delphinidin (chloride)
Synonyms
DELPHINIDIN ()
DELPHINIDIN CHLORIDE ()
P&D ID
PD020059
CAS
528-53-0
8012-95-1
Tags
drug candidate
available
Drug indication
Cardiovascular disease
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
90
DESCRIPTION
Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in vascular relaxation. At the dose of 1-40 ??M, epithelial growth factor receptor signaling and estrogen receptor ?? expression were inhibited, which was associated with apoptosis and autophagy. Delphinidin chloride regulates JAK/STAT3 and MAPKinase signaling. Delphinidin also inhibited the histone acetyltransferase activity of p300/CBP (IC50 was about 30 ??M).
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
4
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
338.02
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
6
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
-0.38
TPSA
132.68
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.26
Structural alerts
2
Aggregator (Nuisance compounds)
Aggregators
Aggregation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
EGFR
JAK
STAT
Pathway
Epigenetics
JAK/STAT Signaling
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Source data
