General
Preferred name
L-759,633
Synonyms
P&D ID
PD019827
CAS
174627-50-0
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
L-759,633 is a potent cannabinoid receptor (CB2) agonist with 163-fold selectivity for CB2 over CB1. L-759,633 exhibits great potency against forskolin-stimulated cyclic AMP production in CB2-transfected cells than in CB1-transfected cells.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
Guide to Pharmacology
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
384.3
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
1
cLogP
7.55
TPSA
18.46
Fraction CSP3
0.69
Chiral centers
2.0
Largest ring
6.0
QED
0.36
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
