General
Preferred name
oxytocin
Synonyms
α-Hypophamine ()
Oxytocic hormone ()
Oxytocin (Syntocinon) ()
¦Á-Hypophamine ()
oxytocin, inhaled, GlaxoSmithKline ()
H-Cys(1)-Tyr-Ile-Gln-Asn-Cys(1)-Pro-Leu-Gly-NH2 ()
Oxytocin (acetate) ()
[3H]OT (human, mouse, rat) ()
Alpha-hypophamine ()
TNX-1900 ()
Pitocin ()
Syntocinon ()
Oxytocine ()
Oxytocinum ()
TTA-121 ()
Syntometrine ()
Orasthin ()
Oxitocina ()
Intertocine s ()
TNX1900 ()
Endopituitrina ()
P&D ID
PD019681
CAS
50-56-6
6233-83-6
Tags
available
drug
Approved by
FDA
First approval
1980
Drug indication
Lactation failure
Autism spectrum disorder
Drug Status
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Oxytocin (¦Á-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma[1][2].
DESCRIPTION Inhibitor of alpha-MSH release; inhibits opioid effects in vivo (Tocris Bioactive Compound Library)
DESCRIPTION Oxytocin (Syntocinon) is a mammalian neuropituitary hormone, a pleiotropic hypothalamic peptide and ligand for the oxytocin receptor, which contributes to labor, lactation, and pro-social behavior. Oxytocin has the ability to stimulate mammary secretion of breast milk, promote contraction of uterine smooth muscle during labor, and facilitate mothering. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
18
Cayman Chemical Bioactives
11799
ChEMBL Approved Drugs
CHEMBL395429
ChEMBL Drugs
CHEMBL395429
Drug Repurposing Hub
DrugCentral
2042
DrugCentral Approved Drugs
2042
DrugMAP
DMDL27I
DrugMAP Approved Drugs
DMDL27I
Guide to Pharmacology
2174
2176
JUMP-Target 1 Compound Set
439302
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL395429
Mcule NIBR MoA Box Subset
MCULE-1193319923
MedChem Express Bioactive Compound Library
HY-17571
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
Oxytocin-Acetate(Syntocinon)
TargetMol Bioactive Compound Library
T5026
Tocris Bioactive Compound Library
1910
External IDs
49
Properties
(calculated by RDKit )
Molecular Weight
1006.44
Hydrogen Bond Acceptors
15
Hydrogen Bond Donors
12
Rotatable Bonds
17
Ring Count
3
Aromatic Ring Count
1
cLogP
-3.61
TPSA
399.53
Fraction CSP3
0.6
Chiral centers
9.0
Largest ring
20.0
QED
0.07
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Oxytocin Receptor
AVPR1A, AVPR1B, AVPR2, OXTR
AVPR1A
Endogenous Metabolite
Primary Target
Oxytocin Receptors
MOA
Agonist
OXTR agonist
oxytocin receptor agonist
Member status
member
Indication
labor induction
Pathway
Endocrinology/Hormones
GPCR/G protein
Metabolic Enzyme/Protease
Source data