General
Preferred name
Ro 01-6128
Synonyms
Ro01-6128 ()
P&D ID
PD019490
CAS
302841-86-7
Tags
drug candidate
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ro 01-6128 is a positive allosteric modulator of mGluR1[1].
DESCRIPTION Ro 01-6128 is a positive allosteric modulator of mGluR1 that potentiates glutamate-induced calcium release (EC50 = 104 nM). Ro 01-6128 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate with an EC50 value of 248 nM and potentiates glutamate-induced cAMP production with an EC50 value of 21.5 μM. (BOC Sciences Bioactive Compounds)
DESCRIPTION 5-HT2A antagonist; also D2 antagonist; atypical antipsychotic (Tocris Bioactive Compound Library)
Compound Sets
10
BOC Sciences Bioactive Compounds
ro-01-6128-cas-302841-86-7-item-170166
Cayman Chemical Bioactives
11991
Concise Guide to Pharmacology 2017/18
1386
Concise Guide to Pharmacology 2019/20
1386
Concise Guide to Pharmacology 2021/22
1386
Concise Guide to Pharmacology 2023/24
1386
DrugMAP
DM0AC84
Guide to Pharmacology
1386
MedChem Express Bioactive Compound Library
HY-107507
Tocris Bioactive Compound Library
4348
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
283.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
3.09
TPSA
55.4
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.94
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
Glutamate (Metabotropic) Group I Receptors
MOA
Modulator
Pathway
GPCR/G protein
Neuronal Signaling
Target
mGluR
Source data