General
Preferred name
Ro 67-4853
Synonyms
Ro67-4853 ()
P&D ID
PD019489
CAS
302841-89-0
Tags
drug candidate
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 161
DESCRIPTION Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration.
DESCRIPTION Ro 67-4853 is a positive allosteric modulator of metabotropic glutamate 1 receptors (mGluR1) (pEC50 value is 7.16 for the rat mGlu1a receptor). It also enhance glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors. (BOC Sciences Bioactive Compounds)
DESCRIPTION Positive allosteric modulator of mGlu1 receptors (Tocris Bioactive Compound Library)
Compound Sets
5
BOC Sciences Bioactive Compounds
ro-67-4853-cas-302841-89-0-item-170163
Cayman Chemical Bioactives
11992
DrugMAP
DMD93NP
Guide to Pharmacology
1387
Tocris Bioactive Compound Library
4347
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
325.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.98
TPSA
64.63
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
Glutamate (Metabotropic) Group I Receptors
MOA
Modulator
Source data