General
Preferred name
Demethoxycurcumin
Synonyms
Curcumin II ()
Desmethoxycurcumin ()
Monodemethoxycurcumin ()
(1E,6E)-Demethoxycurcumin ()
Demethoxy curcumin ()
P&D ID
PD019368
CAS
24939-17-1
22608-11-3
33171-16-3
Tags
drug candidate
nuisance
natural product
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Natural demethoxy curcuminoid. Anticancer, antiproliferative and antioxidant activity. Inhibits various signaling pathways including Wnt/β-catenin, AMPK and MAPK.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
4
Organisms
0
Compound Sets
9
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
Other bioactive compounds
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
338.12
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
3.36
TPSA
83.83
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
1
Nonspecific/NOS
Curcuminoids
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Pathway
Anti-infection
Apoptosis
Autophagy
Target
Bacterial
Immunology & Inflammation related
Solubility
Soluble in DMSO (Slightly), Methanol (Slightly)
Source data
