General
Preferred name
Demethoxycurcumin
Synonyms
Curcumin II ()
Monodemethoxycurcumin ()
Desmethoxycurcumin ()
(E/Z)-Demethoxycurcumin ()
p-Hydroxycinnamoyl-feruloylmethane ()
(1E,6E)-Demethoxycurcumin ()
Demethoxy curcumin ()
P&D ID
PD019368
CAS
22608-11-3
24939-17-1
33171-16-3
Tags
available
drug candidate
nuisance
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research[1][2][3][4][5].
DESCRIPTION
(E/Z)-Demethoxycurcumin (p-Hydroxycinnamoyl-feruloylmethane) is a curcuminoid isolated from curcuma species, with anticoagulative active[1].
PRICE
35
DESCRIPTION
Natural demethoxy curcuminoid. Anticancer, antiproliferative and antioxidant activity. Inhibits various signaling pathways including Wnt/β-catenin, AMPK and MAPK.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
1. Demethoxycurcumin (Desmethoxycurcumin) has antioxidant activity. 2. Demethoxycurcumin has anti-inflammatory activity. 3. Demethoxycurcumin has anti-proliferative activity. 4. Demethoxycurcumin has anti-acanthamoebic effect. 5. Demethoxycurcumin is a potential additive natural product in combination with chemotherapeutic agents in drug-resistant cancers. 6. Demethoxycurcumin inhibits energy metabolic and oncogenic signaling pathways through AMPK activation in triple-negative breast cancer cells.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
4
Organisms
0
Compound Sets
9
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Nuisance compounds in cellular assays
Other bioactive compounds
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
338.12
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
3.36
TPSA
83.83
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
1
Nonspecific/NOS
Curcuminoids
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Autophagy
Microbiology/virology
oxidation-reduction
Anti-infection
Immunology/Inflammation
Neuronal Signaling
Target
Bacterial
Cholinesterase (ChE)
NO Synthase
Immunology & Inflammation related
antioxidant
Solubility
Soluble in DMSO (Slightly), Methanol (Slightly)
Source data
