General
Preferred name
L-AP4
Synonyms
L-APB ()
L-AP 4 ()
L-AP4 (monohydrate) ()
L-APB (monohydrate) ()
P&D ID
PD019101
CAS
23052-81-5
145236-29-9
2247534-79-6
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Group I mGlu antagonist; also phosphoserine phosphatase inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION L-AP4 is a selective group III metabotropic glutamate receptor (mGluR) agonist. It also acts as an agonist at the quisqualate-sensitized AP6 site in hippocampus. L-AP4 is a synaptic depressant. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
12
BOC Sciences Bioactive Compounds
l-ap4-cas-23052-81-5-item-58873
Cayman Chemical Bioactives
14538
Concise Guide to Pharmacology 2017/18
1410
Concise Guide to Pharmacology 2019/20
1410
Concise Guide to Pharmacology 2021/22
1410
Concise Guide to Pharmacology 2023/24
1410
DrugMAP
DMPJFGI
Guide to Pharmacology
1410
1412
MedChem Express Bioactive Compound Library
HY-100781B
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
0103
ZINC Tool Compounds
ZINC000002033983
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
183.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.03
TPSA
120.85
Fraction CSP3
0.75
Chiral centers
1.0
Largest ring
0.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mGluR
Pathway
GPCR/G protein
Neuronal Signaling
Primary Target
Glutamate (Metabotropic) Group III Receptors
MOA
Agonist
mgluR4 Agonists
mgluR8 Agonists
Member status
virtual
Source data