General
Preferred name
NF449
Synonyms
NF 449 ()
NF449 (octasodium) ()
NF449 (sodium salt) ()
P&D ID
PD019068
CAS
627034-85-9
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AMPA antagonist/weak NMDA antagonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
9
Cayman Chemical Bioactives
13324
Concise Guide to Pharmacology 2017/18
4267
Concise Guide to Pharmacology 2019/20
4267
Concise Guide to Pharmacology 2021/22
4267
Concise Guide to Pharmacology 2023/24
4267
DrugMAP
DM816Z2
Guide to Pharmacology
4267
MedChem Express Bioactive Compound Library
HY-112461A
Tocris Bioactive Compound Library
1391
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
1503.75
Hydrogen Bond Acceptors
29
Hydrogen Bond Donors
6
Rotatable Bonds
18
Ring Count
6
Aromatic Ring Count
6
cLogP
-24.4
TPSA
615.13
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.03
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Purinergic (P2X) Receptors
MOA
Antagonist
Pathway
Membrane Transporter/Ion Channel
Target
P2X Receptor
Source data