General
Preferred name
AG1295
Synonyms
AG-1295, NSC 380341, Tyrphostin AG-1295 ()
AG 1295 ()
AG-1295 ()
P&D ID
PD019059
CAS
71897-07-9
Tags
available
drug candidate
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AG 1295 is a selective platelet-derived growth factor receptor (PDGFR) tyrosine-kinase inhibitor. AG1295 abolishes autophosphorylation of the PDGFR whereas not affects the autophosphorylation of the EGF receptor[1][2][3][4].
PRICE 39
DESCRIPTION AG 1295 is a cell-permeable, reversible, ATP-competitive, and selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine kinase . (GtoPdb)
DESCRIPTION AG 1295 is a selective platelet-derived growth factor receptor (PDGFR) tyrosine-kinase inhibitor. It is a potential antiproliferative agent. It is used for diseases caused by the hyperactivity of PTKs. (Enamine Bioactive Compounds)
DESCRIPTION Tyrphostin AG 1295 is a selective inhibitor of PDGFR (platelet-derived growth factor receptor) protein tyrosine kinase (PDGF-receptor PTK)(IC50 = 500 nM) and PDGF-dependent DNA synthesis (IC50 = 2.5 μM) in Swiss/3T3 cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION AG 1295, a selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine-kinase, effectively halts PDGFR autophosphorylation without impacting the autophosphorylation of the EGF receptor[1][2][3][4]. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
9
BOC Sciences Bioactive Compounds
ag1295-cas-71897-07-9-item-84-465369
Cayman Chemical Bioactives
14529
DrugMAP
DMT10C2
Enamine Bioactive Compounds
EBC-00586
Enamine BioReference Compounds
Guide to Pharmacology
5914
MedChem Express Bioactive Compound Library
HY-101957
TargetMol Bioactive Compound Library
T14137
ZINC Tool Compounds
ZINC000000257983
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
234.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
3.91
TPSA
25.78
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PDGFR
Pathway
Angiogenesis
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Solubility
Soluble in DMSO (10 mg/ml), and dichloromethane
Source data